Xanthan Gum Solution
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Prepare Xanthan Gum Solution of the designated percentage strength as follows (see Pharmaceutical Compounding—Nonsterile Preparations 〈795〉).
| Xanthan Gum (for a 0.1% solution) | 100 mg |
| Xanthan Gum (for 1.0% solution) | 1.0 g |
| Methylparaben | 100 mg |
| Propylparaben | 20 mg |
| Puried Water, a sucient quantity to make | 100 mL |
Dissolve a weighed quantity of Propylparaben in Purified Water with heating to 50° and stirring. Cool, and dilute quantitatively, and stepwise if necessary, with Purified Water to obtain 90 mL of solution containing 20 mg of Propylparaben. Heat to 50", and add the Methylparaben, with stirring, to dissolve. Cool, stir with a blender, slowly sift the Xanthan Gum into the vortex, and continue to blend for 2 min after the Xanthan Gum has been added. Add 10 mL of Purified Water, and blend for 5 min. Allow to stand for 1 h for excess foam to subside, and remove most of the remaining foam by passing the solution through a strainer. Add Purified Water, if necessary, to make the final volume 100 mL, and stir. [NOTE-Depending on the volume needed and the equipment available, adjust the formula proportionately.]
2 ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Preserve in tight, light-resistant containers, and store at controlled room temperature.
LABELING: Label it to state, as part of the official title, the percentage content of Xanthan Gum.
BEYOND-USE DATE: Six weeks after the day on which it was compounded
