Vinylpyrrolidinone
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(1-Vinyl-2-pyrrolidinone; 1-Vinyl-2-pyrrolidone; N-Vinylpyrrolidinone; N-Vinylpyrrolidone), C6H9NO 111.14 CAS RN®: 88-12-0. Colorless liquid.
Assay: Inject an appropriate volume into a gas chromatograph (see Chromatography 621〉) equipped with a flame-ionization detector, helium being used as the carrier gas. The following conditions have been found suitable: a 0.25-mm × 30-m capillary column coated with a 1-μm layer of G2; the injection port temperature is maintained at 250°; the detector temperature is maintained at 300°; and the column temperature is maintained at 100° and programmed to rise 10° per min to 250°. The area of the C H NO peak is not less than 99.0% of the total peak area.
Water Determination, Method I 〈921〉: not more than 0.1%, determined on 2.5 g, using a mixture of 50 mL of methanol and 10 mL of butyrolactone as the solvent.
[Note - A suitable grade is available from Merck KGaA/EMD chemicals, catalogue number 8.08518.0250, www.emdchemicals.com.]
