Vehicle for Oral Suspension
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
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1 DEFINITION
Prepare Vehicle for Oral Suspension as follows (see Pharmaceutical Compounding—Nonsterile Preparations 〈795〉).
| Cellulose, Microcrystalline | 800mg |
| Xanthan Gum | 200mg |
| Carrageenan | 150mg |
| Carboxymethylcellulose Sodium (High Viscosity) | 25mg |
| Citric Acid | 250mg |
| Sodium Phosphate, Dibasic | 120mg |
| Simethicone | 0.1mL |
| Potassium Sorbate | 100mg |
| Methylparaben | 100mg |
| Purified Water, a suficient quantity to make | 100mL |
Calculate the quantity of each ingredient required for the total amount to be prepared. Accurately weigh/measure each ingredient. Heat about 90 mL of the Purified Water to 70°–75°. Dissolve the Methylparaben, followed by the Citric Acid, Dibasic Sodium Phosphate, and Potassium
Sorbate in the heated water. Remove from the heat. With constant mixing, slowly sprinkle the Microcrystalline Cellulose, Xanthan Gum,
Carrageenan, and Carboxymethylcellulose Sodium into the mixture. Continue to stir until fully hydrated, add the Simethicone, and mix well. Add sufficient Purified Water to volume, and mix well. Adjust the pH if necessary. Package, and label.
2 SPECIFIC TESTS
pH 〈791〉: An apparent pH between 4.0 and 5.0
3 ADDITIONAL REQUIREMENTS
Packaging and Storage: Package in a tight, light-resistant container, and store at controlled room temperature.
Labeling: Label it to indicate that it is for use in compounding oral solutions and suspensions.
Change to read:
Beyond-Use Date: NMT 6 months after preparation. (CN 1-Nov-2023)
