Trolamine

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

DOWNLOAD PDF HERE

C₆H₁₅NO₃  149.19

Ethanol, 2,2',2"-nitrilotris-;

2,2',2"-Nitrilotriethanol CAS RN^®: 102-71-6.

1 DEFINITION

Trolamine is a mixture of alkanolamines consisting largely of triethanolamine [N(C₂H₄OH)₃] containing some diethanolamine [NH(C₂H₄OH)₂] and monoethanolamine [NH₂(C₂H₄OH)]. It contains NLT 99.0% and NMT 107.4% of alkanolamines, calculated on the anhydrous basis as N(C₂H₄OH)₃.

2 IDENTIFICATION

Change to read:

2.1 A. SPECTROSCOPIC IDENTIFICATION TESTS (197), Infrared Spectroscopy: 197F (CN 1-MAY-2020)

2.2 B.

Analysis 1: To 1 mL add 0.1 mL of cupric sulfate TS.

Acceptance criteria 1: A deep blue color is produced.

Analysis 2: Add 5 mL of 1 N sodium hydroxide, and concentrate to one-third of the original volume by boiling.

Acceptance criteria 2: The blue color remains.

2.3 C.

Analysis: To 1 mL add 0.3 mL of cobaltous chloride TS.

Acceptance criteria: A carmine red color is produced.

3 ASSAY

3.1 PROCEDURE

Sample: 2 g of Trolamine

Analysis: Transfer the Sample to a 300-mL conical flask. Add 75 mL of water and 2 drops of methyl red TS, and titrate with 1 N hydrochloric acid VS. Each mL of 1 N hydrochloric acid is equivalent to 149.2 mg of triethanolamine, expressed as N(C₂H₄OH)₃.

Acceptance criteria: 99.0%-107.4% on the anhydrous basis

4 IMPURITIES

RESIDUE ON IGNITION (281): NMT 0.05%

5 SPECIFIC TESTS

SPECIFIC GRAVITY (841): 1.120-1.128

REFRACTIVE INDEX (831): 1.481-1.486 at 20°

WATER DETERMINATION, Method I(921): NMT 0.5%, using a mixture of glacial acetic acid and methanol (1:4) as the solvent

6 ADDITIONAL REQUIREMENTS

PACKAGING AND STORAGE: Preserve in tight, light-resistant containers.

USP REFERENCE STANDARDS (11)

USP Trolamine RS