Triflupromazine
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C₁₈H₁₉F₃N₂S 352.42
10H-Phenothiazine-10-propanamine, N,N-dimethyl-2-(trifluoromethyl)-.
10-3-(Dimethylamino)propyl-2-(trifluoromethyl)phenothiazine CAS RN®: 146-54-3; UNII: RO16TQF95Y.
Triflupromazine contains not less than 97.0 percent and not more than 103.0 percent of C₁₈H₁₉F₃N₂S.
1 Packaging and storage
Preserve in tight, light-resistant containers.
1.1 USP Reference standards 〈11〉
USP Triflupromazine Hydrochloride RS
[Note-Throughout the following procedures, protect test or assay specimens, the Reference Standard, and solutions containing them, by conducting the procedures without delay, under subdued light, or using low-actinic glassware.]
2 Identification
A: It meets the requirements under Identification-Organic Nitrogenous Bases 〈181〉, USP Triflupromazine Hydrochloride RS being used, and 0.01 N hydrochloric acid being used in place of water to dissolve the specimen.
Change to read:
B: Spectroscopic Identification Tests 〈197〉, Ultraviolet-Visible Spectroscopy: 197U
Solution: 7 µg per mL.
Medium: 0.5 N sulfuric acid.
Absorptivities at 255 nm do not differ by more than 3.0%.
Residue on ignition 〈281〉: not more than 0.2%.
Ordinary impurities 〈466〉
- Test solution: acetone.
- Standard solution: acetone.
- Eluant: a mixture of chloroform and methanol (4:1).
- Visualization: 1.
3 Assay
Dissolve about 800 mg of Triflupromazine, accurately weighed, in 100 mL of glacial acetic acid. Add crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 35.24 mg of C₁₈H₁₉F₃N₂S.
