Triamcinolone Acetonide Dental Paste

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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» Triamcinolone Acetonide Dental Paste is Triamcinolone Acetonide in a suitable emollient paste. It contains not less than 90.0 percent and not more than 115.0 percent of the labeled amount of C₂₄H₃₁FO₆

1 Packaging and storage-

Preserve in tight containers.

2 USP REFERENCE STANDARDS (11)-

USP Triamcinolone Acetonide RS

2.1 Identification-

It responds to the Identification test under Triamcinolone Acetonide Cream.

2.2 MICROBIAL ENUMERATION TESTS (61) and TESTS FOR SPECIFIED MICROORGANISMS (62)-

It meets the requirements of the tests for absence of Staphylococcus

aureus and Pseudomonas aeruginosa.

2.3 MINIMUM FILL (755)

Meets the requirements.

2.4 Assay-

Mobile phase-Prepare as directed in the Assay under Triamcinolone Acetonide Cream.

Internal standard solution and Standard preparation-Prepare as directed in the Assay under Triamcinolone Acetonide Cream.

Assay preparation-Transfer an accurately weighed quantity of Dental Paste, equivalent to about 1.5 mg of triamcinolone acetonide, to a screw-cap tube. Add 20.0 mL of Internal standard solution, cap, and place in a sonic bath for 15 to 20 minutes. Place in a water bath at 70° for 5 minutes, then swirl for 1 minute. Repeat the heating and swirling sequence once. Cool in an ice-methanol bath for 15 minutes, then centrifuge for 10 minutes at -5°. Mix an accurately measured volume of the supernatant with an equal volume of Mobile phase. Place in an ice-methanol bath for 15 minutes, then centrifuge for 15 minutes. Draw off and discard the upper phase. Filter the lower phase to obtain a clear solution.

Procedure-Proceed as directed for Procedure in the Assay under Triamcinolone Acetonide Cream.