Thromboplastin
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
CAS RN®: 9035-58-9.-Buff-colored powder, or opalescent or turbid suspension. It exhibits thrombokinase activity derived from the acetone-extracted brain and/or lung tissue of freshly killed rabbits. It may contain sodium chloride and calcium chloride in suitable proportions, and it may contain a suitable antimicrobial agent. It is used in suspension form for the determination of the prothrombin time and activity of blood. Its thrombokinase activity is such that it gives a clotting time of 11 to 16 seconds with normal human plasma and the proper concentration of calcium ions. Store in tight containers, preferably at a temperature below 5°.
LOSS ON DRYING (731):
[NOTE-This test is applicable only to the dry form.]
Dry it in vacuum at 60° for 6 hours: it loses not more than 5.0% of its weight.
