Theobromine
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C7H8N4O2 180.17 CAS RN®: 83-67-0.—White, crystalline solid. Very slightly soluble in water and in alcohol; almost insoluble in benzene, in ether, and in chloroform.
Assay: Dissolve about 34 mg, accurately weighed, in 50 mL of glacial acetic acid. Titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 18.02 mg of C7H8N4O2 . Not less than 95% is found.
