Tetramethylammonium Hydroxide, Pentahydrate
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(CH3)4NOH · 5H2O 181.23 CAS RN®: 10424-65-4. - White to off-white crystals. Is hygroscopic. Strong base. Keep well-closed. Soluble in water and in methanol.
Assay: Accurately weigh about 800 mg, dissolve in 100 mL of water, and titrate with 0.1 N hydrochloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N hydrochloric acid is equivalent to 18.22 mg of (CH3)4NOH · 5H2O: not less than 98% is found.
