Sugar-Free Suspension Structured Vehicle
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Prepare Sugar-Free Suspension Structured Vehicle as follows (see Pharmaceutical Compounding—Nonsterile Preparations 〈795〉).
| Xanthan Gum | 0.20 g |
| Saccharin Sodium | 0.20 g |
| Potassium Sorbate | 0.15 g |
| Citric Acid | 0.10 g |
| Sorbitol | 2.0 g |
| Mannitol | 2.0 g |
| Glycerin | 2.0 mL |
| Purified Water (vừa đủ) | 100 mL |
Transfer 30 mL of Purified Water to a beaker, placing it on an electric hot plate and stirrer. Using moderate heat, stir to form a vortex, and slowly sprinkle the Xanthan Gum into the vortex. In a separate beaker, dissolve the Saccharin Sodium, Potassium Sorbate, and Citric Acid in 50 mL of Purified Water. Using moderate heat, incorporate the Sorbitol, Mannitol, and Glycerin into this mixture. Add to this mixture the previously prepared xanthan gum dispersion. Add a sufficient quantity of Purified Water to obtain a nal volume of 100 mL, and mix.
2 ADDITIONAL REQUIREMENTS
Packaging and Storage: Package in tight, light-resistant containers. Store at room temperature, and avoid freezing.
Labeling: Label it to state that it must be well shaken before use.
Beyond-Use Date: NMT 30 days after the date on which it was compounded
