Sodium Pyruvate
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
CH3COCO2Na 110.04 CAS RN®: 113-24-6.—White to practically white powder or crystalline solid. Soluble in water.
Assay: Transfer about 300 mg, accurately weighed, to a high-form titration beaker, add 150 mL of glacial acetic acid, and stir until dissolved. Titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically, using a glass electrode and a calomel electrode modified to use 0.1 N tetramethylammonium chloride in methanol as the electrolyte. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 11.00 mg of CH3COCO2Na: not less than 98.0% is found.
Solubility: Dissolve 1.5 g in 25 mL of water: the solution is clear and complete.
Free Acid: Dissolve 10 g in 150 mL of water, and titrate with 0.5 N sodium hydroxide VS, determining the endpoint potentiometrically: not more than 2.8 mL of 0.5 N sodium hydroxide is consumed (about 1% as C3H4O3).
