Sodium Phosphates Oral Solution
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Sodium Phosphates Oral Solution is a solution of Dibasic Sodium Phosphate and Monobasic Sodium Phosphate, or Dibasic Sodium Phosphate and Phosphoric Acid, in Purified Water. It contains, in each 100 mL, not less than 16.2 g and not more than 19.8 g of dibasic sodium phosphate (NaH2PO4· H2O), and not less than 43.2 g and not more than 52.8 g of monobasic sodium phosphate (NaH2PO4· H2O).
Packaging and storage—Preserve in tight containers.
Identification—It responds to the tests for Sodium 〈191〉 and for Phosphate 〈191〉.
Specific gravity 〈841〉: between 1.333 and 1.366.
pH 〈791〉: between 4.4 and 5.2.
Assay—Pipet 25.0 mL of Oral Solution into a 500-mL volumetric flask, dilute with water to volume, and mix. Transfer 25.0 mL of this stock solution to a 250-mL beaker, and add 15.0 mL of 0.5 N sodium hydroxide and 75 mL of water. Proceed as directed in the Assay under Sodium Phosphates Rectal Solution, beginning with “Titrate the excess base.
