Sodium Methoxide
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
CH3ONa 54.02 CAS RN®: 124-41-4.-Fine, white powder. Reacts violently with water with evolution of heat. Soluble in alcohol and in methanol.
Assay: Transfer about 220 mg to a tared, glass-stoppered flask, and weigh accurately. Dissolve the test specimen in about 10 mL of methanol, then add 100 mL of water slowly, with stirring. Add phenolphthalein TS, and titrate with 0.1 N hydrochloric acid VS to a colorless endpoint: each mL of 0.1 N hydrochloric acid VS is equivalent to 5.402 mg of CH3ONa . Not less than 98.0% is found.
