Sodium Borohydride
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
NaBH4 37.83 CAS RN®: 16940-66-2.-White, crystalline solid. Freely soluble in water, soluble (with reaction) in methanol. Its solutions are rapidly decomposed by boiling.
1 Assay
Potassium iodate solution: Dissolve 8.917 g, previously dried at 110° to constant weight and accurately weighed, in water to make 1000.0 mL.
Procedure: Dissolve about 500 mg, accurately weighed, in 125 mL of sodium hydroxide solution (1 in 25) in a 250-mL volumetric flask, dilute with the sodium hydroxide solution to volume, and mix. Pipet 10 mL of the solution into a 250-mL iodine flask, add 35.0 mL of Potassium iodate solution, and mix. Add 2 g of potassium iodide, mix, add 10 mL of dilute sulfuric acid (1 in 10), insert the stopper in the flask, and allow to stand in the dark for 3 minutes. Titrate the solution with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is approached. Calculate the amount, in mg, of NaBH4 in the specimen titrated by the formula:
([(35.0)(0.25)] - 0.1V)4.729
in which V is the volume. in mL of 0.1 N sodium thiosulfate used in the titration. Not less than 98% is found.
