Sodium Acetate Solution
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Sodium Acetate Solution is an aqueous solution of Sodium Acetate. It contains not less than 97.0 percent and not more than 103.0 percent (w/w) of the labeled amount of C2H3NaO2.
Packaging and storage—Preserve in tight containers.
Identification—It responds to the tests for Sodium 〈191〉 and for Acetate 〈191〉.
PH 〈791〉: between 7.5 and 9.2, when diluted with carbon dioxide-free water to contain 5% of solids.
Insoluble matter—Dilute a quantity of Solution, equivalent to 20 g of anhydrous sodium acetate, with water to 150 mL, heat to boiling, and digest in a covered beaker on a steam bath for 1 hour. Filter through a tared filtering crucible, wash thoroughly, and dry at 105°: the weight of the residue does not exceed 1 mg (0.005%).
CHLORIDE 〈221〉—A quantity of Solution, equivalent to 1.0 g of anhydrous sodium acetate, shows no more chloride than corresponds to 0.50 mL of 0.020 N hydrochloric acid (0.035%).
SULFATE 〈221〉—A quantity of Solution, equivalent to 10 g of anhydrous sodium acetate, shows no more sulfate than corresponds to 0.50 mL of 0.020 N sulfuric acid (0.005%).
Calcium and magnesium—Dilute a quantity of Solution, equivalent to 1.0 g of anhydrous sodium acetate, to 100 mL with water. To 20 mL of this solution add 2 mL each of 6 N ammonium hydroxide, ammonium oxalate TS, and sodium phosphate TS: no turbidity is produced within 5 minutes.
Potassium—To a quantity of Solution, equivalent to 3.0 g of anhydrous sodium acetate, add 0.2 mL of sodium bitartrate TS: no turbidity is produced within 5 minutes.
Assay—Weigh accurately about 1 g of Solution into a 250-mL conical flask, cautiously add (in a fume hood) 2.6 mL of acetic anhydride, mix, and allow to stand for 5 minutes. Add 25 mL of glacial acetic acid and 2 drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, using 0.5 mL of water, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 8.203 mg of C2H3NaO2.
