Silver Nitrate Ophthalmic Solution

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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1 DEFINITION 

Silver Nitrate Ophthalmic Solution is a solution of Silver Nitrate in a water medium. It contains NLT 0.95% and NMT 1.05% of silver nitrate (AgNO₃). The solution may be buffered by the addition of Sodium Acetate. 

2 IDENTIFICATION 

A. Identification Tests—General, Silver〈191〉andNitrate〈191〉: Meets the requirements 

3 ASSAY 

Procedure 

Sample solution: Place 5 mL of Ophthalmic Solution in a conical flask, dilute with 20 mL of water, and add 1 mL of nitric acid and 1 mL of ferric ammonium sulfate TS. 

Titrimetric system Mode: Direct titration 

Titrant: 0.02 N ammonium thiocyanate VS 

Endpoint detection: Visual 

Analysis: Titrate the Sample solution with Titrant. Each mL of 0.02 N ammonium thiocyanate is equivalent to 3.397 mg of silver nitrate (AgNO₃). 

Acceptance criteria: 0.95%–1.05% 

4 SPECIFIC TESTS 

Clarity and Color of Solution: Clear and colorless 

pH 〈791〉: 4.5–6.0 

Sterility Tests 〈71〉: Meets the requirements 

5 ADDITIONAL REQUIREMENTS 

Packaging and Storage: Preserve it protected from light, in inert, collapsible capsules or in other suitable single-dose containers.