Siliceous Earth, Chromatographic, Silanized
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
-Place about 450 g of purified siliceous earth in a large, open, glass crystallizing dish in a vacuum desiccator containing 30 mL of a suitable silane, e.g., a mixture of 1 volume of dimethyldichlorosilane and 1 volume of trimethylchlorosilane, or a mixture of 1 volume of methyltrichlorosilane and 2 volumes of dimethyldichlorosilane. Apply vacuum intermittently for several hours, until no liquid silane remains. Float the treated purified siliceous earth on water, and gently agitate to allow any uncoated particles to sink. Skim the silanized material off the surface, wash it on a sintered-glass funnel with warm methanol until the filtrate no longer is acidic, and dry at 110°.
