Salicylic Acid Collodion
If you find any inaccurate information, please let us know by providing your feedback here
Tóm tắt nội dung
This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Salicylic Acid Collodion contains NLT 9.5% and NMT 11.5% of salicylic acid (C7H6O3).
Salicylic Acid Collodion is prepared as follows.
| Salicylic Acid | 100 g |
| Flexible Collodion, a sufficient quantity to make | 1000 mL |
Dissolve the Salicylic Acid in about 750 mL of Flexible Collodion. Add a sufficient quantity of the Flexible Collodion to bring the preparation to final volume, and mix.
2 ASSAY
2.1 Procedure
Sample: 5 mL
Solution A: Ether and alcohol (3:1) neutralized to bromothymol blue TS
Titrimetric system
Mode: Direct titration
Titrant: 0.1 N sodium hydroxide VS
Endpoint detection: Visual
Analysis: Transfer the Sample to a 400-mL beaker, rinse the measuring device with three 10-mL portions of Solution A, and add the rinsings to the beaker. Add, with stirring, 5 mL of 100 mg/mL sodium lauryl sulfate solution that was previously neutralized with 0.1 N hydrochloric acid to the distinct yellow color of bromothymol blue TS, and add 20 mL of water. Mix, add 5 drops of bromothymol blue TS, and titrate with the Titrant. Each mL of Titrant is equivalent to 13.81 mg of salicylic acid (C7H6O3).
Acceptance criteria: 9.5%–11.5%
3 ADDITIONAL REQUIREMENTS
Packaging and Storage: Package in tight containers. Store at controlled room temperature, remote from fire.
