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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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Siliceous earth for gas chromatography has been flux-calcined by mixing diatomite with Na2CO3 flux and calcining above 900°. The siliceous
earth is acid-washed, then water-washed until neutral, but not base-washed. The siliceous earth may be silanized by treating with an agent such
as dimethyldichlorosilane [Note—Unless otherwise specified in the individual monograph, silanized support is intended.] to mask surface silanol groups.

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