Pyridoxamine Dihydrochloride
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C8H12N2O2 . 2HCI 241.11 CAS RN: 524-36-7.-White to slightly yellow crystals or crystalline powder. Gradually darkens on exposure to air or sunlight. One g dissolves in about 1 mL of water and in about 60 mL of alcohol. Insoluble in chloroform and in ether. Its solutions are acid.
MELTING RANGE (741): between 225° and 230°, with some decomposition.
1 Residue on Ignition (Reagent test)
not more than 0.15%.
LOSS ON DRYING (731): Dry it at 105° for 2 hours: it loses not more than 0.5% of its weight.
2 Nitrogen Content (Reagent test)
Determine by the Kjeldahl method, using a test specimen previously dried at 105° for 2 hours: between 11.3% and 11.8% of N is found.
Chloride Content: Determine as directed in the test for Chloride Content under Pyridoxal Hydrochloride: between 29.1% and 29.6% of Cl is found.

