Podophyllum Resin Topical Solution
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Podophyllum Resin Topical Solution is a solution in Alcohol consisting of Podophyllum Resin and an alcoholic extract of Benzoin. It contains, in each 100 mL, not less than 10 g and not more than 13 g of hexane-insoluble matter.
[Caution - Podophyllum Resin Topical Solution is highly irritating to the eye and to mucous membranes in general.]
1 Packaging and storage
Preserve in tight, light-resistant containers.
2 Identification
A: A 1 in 5 solution in chloroform is levorotatory.
B: The precipitate obtained as directed in the test for Hexane-insoluble matter responds to Identification test A under Podophyllum Resin.
Alcohol Determination 〈611〉: between 69.0% and 72.0% of C H OH.
3 Hexane-insoluble matter
Using a 10.0-mL quantity of the Topical Solution, proceed as directed for Hexane-insoluble matter under Podophyllum Resin. Multiply the weight of hexane-insoluble matter found by 2.5 to find the amount present in the 10.0 mL taken.
