Neomycin Sulfate and Hydrocortisone Cream
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Neomycin Sulfate and Hydrocortisone Cream contains the equivalent of not less than 90.0 percent and not more than 135.0 percent of the labeled amount of neomycin, and not less than 90.0 percent and not more than 110.0 percent of the labeled amount of hydrocortisone (C21H30O5)
Packaging and storage-Preserve in collapsible tubes or in well-closed containers.
USP REFERENCE STANDARDS (11)
USP Hydrocortisone RS
USP Neomycin Sulfate RS
Identification
A: It meets the requirements for neomycin under Thin-Layer Chromatographic Identification Test (201BNP).
B: The retention time of the major peaks for hydrocortisone in the chromatogram of the Assay preparation corresponds to that in the chromatogram of the Standard preparation, as obtained in the Assay for hydrocortisone.
MINIMUM FILL (755): meets the requirements.
Assay for neomycin-Proceed with Cream as directed in the Assay under Neomycin Sulfate Ointment.
Assay for hydrocortisone-Proceed with Cream as directed in the Assay for hydrocortisone under Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment.
