Neomycin Sulfate and Fluocinolone Acetonide Cream

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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Neomycin Sulfate and Fluocinolone Acetonide Cream contains the equivalent of not less than 90.0 percent and not more than 135.0 percent of the labeled amount of neomycin, and the equivalent of not less than 90.0 percent and not more than 110.0 percent of the labeled amount of fluocinolone acetonide (C₂₄H₃₀F₂O₆).

1 Packaging and storage

Preserve in collapsible tubes or in tight containers.

1.1 USP Reference standards 〈11〉

USP Fluocinolone Acetonide RS

USP Neomycin Sulfate RS

2 Identification

A: It meets the requirements for neomycin under Thin-Layer Chromatographic Identification Test 〈201BNP〉.

B: It meets the requirements for the Identification test under Fluocinolone Acetonide Cream.

Minimum fill 〈755〉: meets the requirements.

3 Assay for neomycin

Proceed with Cream as directed in the Assay under Neomycin Sulfate Cream.

4 Assay for fluocinolone acetonide

Proceed with Cream as directed in the Assay under Fluocinolone Acetonide Cream.