N,N-Dimethyl-1-naphthylamine
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C12H13N 171.24 CAS RN®: 86-56-6.-Pale yellow to yellow, aromatic liquid. Soluble in alcohol and in ether.
Assay: Transfer about 250 mg, accurately weighed, to a suitable beaker, add 100 mL of glacial acetic acid, and dissolve by stirring. When solution is complete, titrate with 0.1 N perchloric acid VS, determining the endpoint potentiometrically. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 17.12 mg of C12H13N. Not less than 98% is found. 12 13
REFRACTIVE INDEX (831): between 1.6210° and 1.6230° at 20°, sodium light being used.
Sulfanilamide Test: Dissolve 20 mg of USP Sulfanilamide RS in 100 mL of water to obtain the Sulfanilamide solution. Into two 150-mL beakers pipet 1.0 mL and 2.5 mL of the Sulfanilamide solution, respectively. Dilute with water to 90 mL. To provide a blank, place 90 mL of water in a third beaker. To each beaker add 8.0 mL of trichloroacetic acid solution (3 in 20) and 1.0 mL of sodium nitrite solution (1 in 1000). Stir the solutions for 5 minutes, then add 10 mL of acetate buffer TS, and 1.0 mL of a 1 in 1000 solution of N,N-dimethyl-1-naphthylamine in alcohol. The pH is about 5 to 6, using pH paper. Stir for an additional 5 minutes, then add 20 mL of glacial acetic acid. The pH is about 3 to 4, using pH paper. In comparison with the blank, the beaker containing 1.0 mL of the Sulfanilamide solution shows a pink color, while the other beaker shows a deep pink to red color.
