Methylbenzothiazolone Hydrazone Hydrochloride
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C8H10CIN3S . H2O 233.7 CAS RN®: 38894-11-0.
(monohydrate form) 215.70
(anhydrous form); CAS RN®: 149022-15-1. (hydrate form)-Use a suitable grade with a content of NLT 97%.
Suitability for Determination of Aldehydes
Sample solution: Transfer 60 µL of 1 g/L of propionaldehyde in aldehyde-free methanol and 5 mL of 4 g/L of methylbenzothiazolone hydrazone hydrochloride in water to a 100-mL volumetric flask containing 2 mL of aldehyde-free methanol. Mix and allow the resulting solution to stand for 30 min. Add 25.0 mL of 2 g/L of ferric chloride in water to the flask and dilute with acetone to volume.
Blank: Transfer 5 mL of 4 g/L of methylbenzothiazolone hydrazone hydrochloride in water to a 100-mL volumetric flask containing 2 mL of aldehyde-free methanol. Mix and allow the resulting solution to stand for 30 min. Add 25.0 mL of 2 g/L of ferric chloride in water to the flask and dilute with acetone to volume.
Instrumental conditions
(See Ultraviolet-Visible Spectroscopy (857).)
Mode: UV-Vis
Wavelength: 660 nm
Analysis
Samples: Sample solution and Blank
Acceptance criteria: The absorbance of the Sample solution is NLT 0.62. (USP 1-Dec-2023)
