Methyl Isobutyl Ketone
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C6H12O 100.16
2-Pentanone, 4-methyl-;
4-Methyl-2-pentanone CAS RN®: 108-10-1.
1 DEFINITION
Methyl Isobutyl Ketone contains NLT 99.0% of methyl isobutyl ketone (C6H12O).
2 IDENTIFICATION
The IR absorption spectrum of a thin lm of it between sodium chloride crystals exhibits maxima, among others, at the following wavelengths, in µm: 5.81 (vs), 6.80 (m), 7.00 (m), 7.09 (m), 7.29 (vs), 7.72 (m), 8.06 (m), 8.31 (sh), 8.53 (s), and 8.91 (m).
3 IMPURITIES
Limit of Nonvolatile Residue
Sample: 50 mL
Analysis: Evaporate the Sample in a tared porcelain dish on a steam bath, and dry at 105° for 1 h. Weigh the residue. Acceptance criteria: NMT 4 mg (0.008%)
4 SPECIFIC TESTS
Specific Gravity 〈841〉: NMT 0.799, indicating NLT 99.0% of methyl isobutyl ketone (C6H12O)
Distilling Range, Method I〈721〉: Between 114° and 117°, a correction factor of 0.046°/mm Hg being applied as necessary
Acidity
Sample: 15.0 mL
Analysis: Mix the Sample with 15 mL of neutralized alcohol, add phenolphthalein TS, and titrate with 0.050 N sodium hydroxide. Acceptance criteria: NMT 0.40 mL is required for neutralization.
5 ADDITIONAL REQUIREMENTS
Packaging and Storage: Preserve in tight containers.
