m-Aminophenol
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(3-Amino-1-Hydroxybenzene), C6H7NO 109.13 CAS RN®: 591-27-5.—Cream-colored to pale yellow flakes. Sparingly soluble in cold water; freely soluble in hot water, in alcohol, and in ether.
Assay: Dissolve about 1.5 g, accurately weighed, in about 400 mL of water in a 500-mL volumetric flask, dilute with water to volume, and mix.
Transfer 25.0 mL of this solution to an iodine flask, add 50.0 mL of 0.1 N bromine VS, dilute with 50 mL of water, add 5 mL of hydrochloric acid, and immediately insert the stopper in the flask. Shake for 1 minute, allow to stand for 2 minutes, and add 5 mL of potassium iodide TS through the slightly loosened stopper. Shake thoroughly, allow to stand for 5 minutes, remove the stopper, and rinse it and the neck of the flask with 20mL of water, adding the rinsing to the flask. Titrate the liberated iodine with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the endpoint is approached. From the volume of 0.1 N sodium thiosulfate used, calculate the volume, in mL, of 0.1 N bromine consumed by the test specimen. Each mL of 0.1 N bromine is equivalent to 1.819 mg of C H NO: not less than 99.5% is found.
Melting Range 〈741〉: between 121° and 123°.
Loss on Drying 〈731〉: Dry it over calcium chloride for 4 hours: the loss in weight is negligible.
Residue on Ignition (Reagent test): negligible, from 2 g.
