Isopropyl Myristate
If you find any inaccurate information, please let us know by providing your feedback here
This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C17H34O2 270.45 CAS RN®: 110-27-0.-Use Isopropyl Myristate (NF monograph). For use as a solvent in sterility test procedures, Isopropyl Myristate conforms to the following additional specification:
pH OF WATER EXTRACT: Transfer 100 mL to a 250-mL centrifuge bottle, add 10 mL of twice-distilled water, close the bottle with a suitable closure, and shake vigorously for 60 minutes. Centrifuge the mixture at 1800 rpm for 20 minutes, aspirate the upper (isopropyl myristate) layer, and determine the pH of the residual water layer: the pH is not less than 6.5.
Isopropyl Myristate not conforming to the test for pH of Water Extract may be rendered suitable for use in sterility test procedures as follows: Using a 20-mm x 20-cm glass column, add activated alumina, and tamp down to a height of 15 cm. Pass 500 mL of the isopropyl myristate through the column, using a slight positive pressure to maintain an even flow, and use the eluate collected directly in the sterility test procedure.
