Isopropamide Iodide
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C23H33IN2O 480.43
Benzenepropanaminium, γ-(aminocarbonyl)-N-methyl-N,N-bis(1-methylethyl)-γ-phenyl-, iodide.
(3-Carbamoyl-3,3-diphenylpropyl) diisopropylmethylammonium iodide CAS RN®: 71-81-8; UNII: E0KNA372SZ.
\Isopropamide Iodide, dried in vacuum at 60° for 2 hours, contains not less than 98.0 percent and not more than 101.0 percent of C23H33IN2O.
Packaging and storage—Preserve in well-closed, light-resistant containers.
USP Reference standards 〈11〉—
USP Isopropamide Iodide RS
Identification—
Change to read:
A: Spectroscopic Identication Tests 〈197〉, Infrared Spectroscopy: 197K .
B: To 5 mL of a solution (1 in 1000) add 5 mL of sodium carbonate solution (1 in 100), 0.5 mL of bromophenol blue TS, and 10 mL of chloroform, and shake for several minutes: the chloroform layer becomes an intense blue in color.
C: A solution (1 in 1000) responds to the tests for Iodide 〈191〉.
Loss on drying 〈731〉—Dry it in vacuum at 60° for 2 hours: it loses not more than 1.0% of its weight.
Residue on ignition 〈281〉: not more than 0.5%, after ignition at 550 ± 25° for 4 hours.
Ordinary impurities 〈466〉—
Test solution: methanol.
Standard solution: methanol.
Eluant: a mixture of methanol, glacial acetic acid, and water (8:1:1).
Visualization: 2.
Assay—Dissolve about 750 mg of Isopropamide Iodide, previously dried and accurately weighed, in 60 mL of glacial acetic acid, add 15 mL of mercuric acetate TS and crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 48.04 mg of C23H33IN2O.
