Isobutyl Acetate
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C6H12O2 116.16 CAS RN®: 110-19-0.-Clear, colorless liquid. Slightly soluble in water. Miscible with alcohol.
Assay: Inject an appropriate specimen into a suitable gas chromatograph (see Chromatography (621)) equipped with a flame-ionization detector, helium being used as the carrier gas. The following conditions have been found suitable: a 0.25-mm x 30-m capillary column coated with G2. The injection port temperature is maintained at 130°; the column temperature is maintained at 30° and programmed to rise 10° per minute to 180° and held there for 10 minutes. The detector temperature is maintained at 300°. The area of the main peak is not less than 99% of the total peak area.
SPECIFIC GRAVITY (841): between 0.863 and 0.868.
REFRACTIVE INDEX (831): between 1.3900 and 1.3920 at 20°.

