Iodipamide
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Iodipamide
C₂₀H₁₄I₆N₂O₆ 1139.76
Benzoic acid, 3,3′-[(1,6-dioxo-1,6-hexanediyl)diimino]bis[2,4,6-triiodo-].
3,3′-(Adipoyldiimino)bis[2,4,6-triiodobenzoic acid]
CAS RN®: 606-17-7; UNII: TKQ858A3VW.
» Iodipamide contains not less than 98.0 percent and not more than 102.0 percent of C₂₀H₁₄I₆N₂O₆, calculated on the anhydrous basis.
Packaging and storage—
Preserve in well-closed containers. Store at 25°, excursions permitted between 15° and 30°.
USP Reference standards 〈11〉—
USP 3-Amino-2,4,6-triiodobenzoic Acid RS
C₇H₄I₃NO₂ 514.83
USP Iodipamide RS
1 Identication—
A: It responds to the Thin-Layer Chromatographic Identication Test 〈201〉, the test solution and the Standard solution being prepared at a concentration of 1 mg per mL in an 0.8 in 1000 solution of sodium hydroxide in methanol, the solvent mixture being a mixture of chloroform, methanol, and ammonium hydroxide (20:10:2), and short-wavelength UV light being used to locate the spots.
B: Heat about 500 mg in a suitable crucible: violet vapors are evolved.
Water Determination, Method I 〈921〉:
not more than 1.0%.
Residue on ignition 〈281〉:
not more than 0.1%.
Free aromatic amine—
Transfer 1.0 g to a 50-mL volumetric ask, and add 12.5 mL of water and 2.5 mL of 1 N sodium hydroxide. To a second 50-mL volumetric ask transfer 4 mL of water, 10 mL of 0.1 N sodium hydroxide, and 1.0 mL of a Standard solution prepared by dissolving a suitable quantity of USP 3-Amino-2,4,6-triiodobenzoic Acid RS in 0.1 N sodium hydroxide (use 0.2 mL of the 0.1 N sodium hydroxide for each 5.0 mg of the Reference standard) and by diluting with water to obtain a solution having a known concentration of 500 µg per mL. Proceed as directed in the test for Free aromatic amine under Diatrizoate Meglumine, beginning with “To a third 50-mL volumetric ask add 5 mL of water.”
Other requirements—
It meets the requirements of the tests for Iodine and iodide under Diatrizoic Acid.
2 Assay—
Transfer about 300 mg of Iodipamide, accurately weighed, to a glass-stoppered, 125-mL conical ask, add 30 mL of 1.25 N sodium hydroxide and 500 mg of powdered zinc, connect the ask to a reux condenser, and reux the mixture for 30 minutes. Cool the ask to room temperature, rinse the condenser with 20 mL of water, disconnect the ask from the condenser, and lter the mixture. Rinse the lter and the ask thoroughly, adding the rinsings to the ltrate. Add 5 mL of glacial acetic acid and 1 mL of tetrabromophenolphthalein ethyl ester TS, and titrate with 0.05 N silver nitrate VS until the yellow precipitate just turns green. Each mL of 0.05 N silver nitrate is equivalent to 9.498 mg of C₂₀H₁₄I₆N₂O₆.
