Helium
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
He 4.00
Helium.
Helium CAS RN®: 7440-59-7; UNII: 206GF3GB41.
>> Helium contains not less than 99.0 percent, by volume, of He.
1 Packaging and storage
Preserve in cylinders.
[NOTE-Reduce the container pressure by means of a regulator. Measure the gases with a gas volume meter downstream from the detector tube in order to minimize contamination or change of the specimens.]
2 Identification
The flame of a burning splinter of wood is extinguished when inserted into an inverted test tube filled with Helium. [NOTE-Use caution.] A small balloon filled with Helium shows decided buoyancy.
3 Odor
Carefully open the container valve to produce a moderate flow of gas. Do not direct the gas stream toward the face, but deflect a portion of the stream toward the nose: no appreciable odor is discernible.
4 Carbon monoxide
Pass 1000 ± 50 mL through a carbon monoxide detector tube (see under Reagents in the section Reagents, Indicators, and Solutions) at the rate specified for the tube: the indicator change corresponds to not more than 0.001%.
5 Air
Not more than 1.0% of air is present, determined as directed in the Assay.
6 Assay
Introduce a specimen of Helium into a gas chromatograph by means of a gas sampling valve. Select the operating conditions of the gas chromatograph such that the standard peak signal resulting from the following procedure corresponds to not less than 70% of the full-scale reading. Preferably, use an apparatus corresponding to the general type in which the column is 6 m in length and 4 mm in inside diameter and is packed with porous polymer beads, which permits complete separation of nitrogen and oxygen from Helium, although the nitrogen and oxygen may not be separated from each other. Use industrial grade helium (99.99%) as the carrier gas, with a thermal-conductivity detector, and control the column temperature: the peak response produced by the assay specimen exhibits a retention time corresponding to that produced by an air-helium certified standard (see under Reagents in the section Reagents, Indicators, and Solutions), and indicates not more than 1.0% of air when compared to the peak response of the air-helium certified standard, and not less than 99.0%, by volume, of He.
