Guaiacol
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(o-Methoxyphenol), C7H8O2 124.14 CAS RN: 95-05-1.-Colorless to yellowish, refractive liquid. Soluble in about 65 parts of water; soluble in sodium hydroxide solution; miscible with alcohol, with chloroform, with ether, and with glacial acetic acid.
Assay: When examined by gas-liquid chromatography, it shows a purity of not less than 98%. The following conditions have been found suitable for assaying it: a 3-mm x 1.8-m stainless steel column containing liquid phase G16 on 60- to 80-mesh support S1A. Helium is the carrier gas, the injection port temperature is maintained at 180°, the column temperature is maintained at 200°, and the flame-ionization detector is maintained at 280°. The retention time is about 8 minutes.
REFRACTIVE INDEX (831): between 1.5430 and 1.5450, at 20°.
