Gitoxin
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C41H64O14 780.94 CAS RN®: 4562-36-1.-White, crystalline powder. Practically insoluble in water, in chloroform, and in ether; slightly soluble in pyridine and in diluted alcohol. Melts at about 250°, with decomposition.
SPECIFIC ROTATION (781): between +3.8° and +4.8°, determined in a solution of pyridine containing 10 mg per mL, with the use of a mercury light at 546.1 nm; between +21° and +25°, determined in a solution of equal parts of chloroform and methanol containing 5 mg per mL, with the use of sodium light.
Suitability: Dissolve 10 mg each of USP Digitoxin RS, previously dried, USP Digoxin RS, previously dried, and gitoxin, respectively, in separate 5-mL portions of a mixture of 2 parts of chloroform and 1 part of methanol, and dilute each with additional solvent mixture to 10 mL. Then proceed as directed in the Identification test under Digoxin. The chromatogram of gitoxin shows one fluorescent spot, located between the digoxin and digitoxin spots.
