Formamide
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
HCONH2 45.04 CAS RN®: 75-12-7.—Use ACS reagent grade.
Preparation for Digitoxin Assay: To ensure freedom from ammonia, treat Formamide as follows. Shake a suitable quantity of formamide with about 10% of its weight of anhydrous potassium carbonate for 15 minutes, and filter. Distill the filtrate in an all-glass apparatus under vacuum at a pressure of about 25 mm of mercury or less. Reject the first portion of distillate containing water, and collect the fraction that boils at about 115° at a pressure of 25 mm of mercury or at 101° at a pressure of 12 mm of mercury. Store in tight containers, protected from light.
