Eugenol
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Phenol, 2-methoxy-4-(2-propenyl)-;
4-Allyl-2-methoxyphenol CAS RN®: 97-53-0; UNII: 3T8H1794QW.
1 DEFINITION
Eugenol is obtained from clove oil and from other sources.
2 IDENTIFICATION
Change to read:
A. Spectroscopic Identification Tests (197), Infrared Spectroscopy: 197F
3 IMPURITIES
HYDROCARBONS
Analysis: Dissolve 1 mL in 20 mL of 0.5 N sodium hydroxide in a 50-mL stoppered tube, add 18 mL of water, and mix.
Acceptance criteria: A clear mixture results immediately, but it may become turbid when exposed to air
LIMIT OF PHENOL
Analysis: Shake 1 ml with 20 ml of water. Filter, and add 1 drop of ferric chloride TS to 5 mL of the clear filtrate
Acceptance criteria: The mixture exhibits a transient grayish green color but not a blue or violet color.
4 SPECIFIC TESTS
SPECIFIC GRAVITY (841); 1.064-1.070
DISTILLING RANGE, Method (721): NLT 95% distills from 250°-255°
REFRACTIVE INDEX (831): 1.540-1.542 at 20°
SOLUBILITY IN 70% ALCOHOL: One volume dissolves in 2 volumes of 70% alcohol.
5 ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Preserve in tight, light-resistant containers.
