Ethylenediamine
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
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Ethylenediamine contains not less than 98.0 percent and not more than 100.5 percent, by weight, of C2H8N2.
[Caution—Use care in handling Ethylenediamine because of its caustic nature and the irritating properties of its vapor.]
[Note—Ethylenediamine is strongly alkaline and may readily absorb carbon dioxide from the air to form a nonvolatile carbonate. Protect Ethylenediamine against undue exposure to the atmosphere.]
1 Packaging and storage
—Preserve in well-filled, tight, glass containers.
Identification—To 2 mL of cupric sulfate solution (1 in 100) add 3 drops of a solution of Ethylenediamine (1 in 6), and shake: a purplish blue color is produced.
2 Assay
—Weigh accurately about 1 mL of Ethylenediamine in a tared, glass-stoppered flask containing about 25 mL of water. Dilute with water to about 75 mL, add a mixed indicator of bromocresol green TS and methyl red TS (5 in 6), mix, and titrate with 1 N hydrochloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 1 N hydrochloric acid is equivalent to 30.05 mg of C2H8N2.
