Ethylene Glycol
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
HOCH2CH2OH 62.07 CAS RN®: 107-21-1.—Clear, colorless, slightly viscous, hygroscopic liquid. Slightly soluble in ether; practically insoluble in benzene. Miscible with water and with alcohol.
• Specific Gravity 〈841〉: about 1.11.
• Boiling Range (Reagent test): between 194° and 200°.
• Residue on Ignition: Evaporate 100 mL (110 g) in a tared evaporating dish over a flame until the vapors continue to burn after the flame is
removed. Allow the vapors to burn until the specimen is consumed. Ignite at 800 ± 25° for 1 hour, cool, and weigh: the residue weighs not more than 5.5 mg (0.005%).
• Acidity: Add 0.2 mL of phenol red TS to 50 mL of water, and titrate with 0.1 N sodium hydroxide to a red endpoint. Add 50 mL (55 g) of ethylene glycol, and titrate with 0.1 N sodium hydroxide: not more than 1 mL is required to restore the red color (0.01% as CH3COOH).
• Chloride (Reagent test): A 4.5-mL (5-g) portion shows not more than 0.025 mg of Cl (5 ppm).
• Water Determination, Method I 〈921〉: not more than 0.20%.
