Dimethyl Phthalate
If you find any inaccurate information, please let us know by providing your feedback here
This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C10H10O4 194.19 CAS RN: 131-11-3.—Viscous, colorless liquid.
Assay
Mobile phase: Prepare a filtered and degassed mixture of chromatographic n-heptane and n-propyl alcohol (HPLC grade) (97:3). Make
adjustments if necessary (see System Suitability under Chromatography (621)).
Standard solution: Dissolve a suitable quantity of dimethyl phthalate in Mobile phase to obtain a solution having a known concentration of about 0.26 mg per mL.
Procedure: Inject about 20 µL into a suitable liquid chromatograph (see Chromatography (621)) equipped with a 238-nm detector and a 4.6-mm x 25-cm column that contains packing L10. The flow rate is about 1.0 mL per minute. The area of the dimethyl phthalate peak is not less than 99% of the total peak area.
REFRACTIVE INDEX (831): between 1.514 and 1.518 at 20°.
