Cobaltous Chloride CS
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
—Dissolve about 65 g of cobaltous chloride (CoCl · 6H O) in enough of a mixture of 25 mL of hydrochloric acid and 975 mL of water to make 1000 mL. Pipet 5 mL of this solution into a 250-mL iodine flask, add 5 mL of Hydrogen peroxide TS and 15 mL of sodium hydroxide solution (1 in 5), boil for 10 minutes, cool, and add 2 g of potassium iodide and 20 mL of dilute sulfuric acid (1 in 4). When the precipitate has dissolved, titrate the liberated iodine with 0.1 N sodium thiosulfate VS, adding 3 mL of starch TS as the indicator. Perform a blank determination with the same quantities of the same reagents, and make any necessary correction. Each mL of 0.1 N sodium thiosulfate is equivalent to 23.79 mg of CoCl2 · 6H2O. Adjust the final volume of the solution by the addition of enough of the mixture of hydrochloric acid and water so that each mL contains 59.5 mg of CoCl2· 6H2O.
