Cinchonine
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C19H22N2O 294.39 CAS RN®: 118-10-5.—White crystals, crystalline or granular powder. Slightly soluble in chloroform, sparingly soluble in alcohol, and practically insoluble in water.
Assay: Dissolve about 125 mg, accurately weighed, in 50 mL of glacial acetic acid. Add a few drops of p-naphtholbenzein TS, and titrate with 0.1 N perchloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 14.72 mg of C19H22N2O. Not less than 99.0% is found.
Loss on Drying〈731〉: Dry it at 105° to constant weight: it loses not more than 1.0% of its weight.
Melting Range〈741〉: between 255° and 261°.
Specific Rotation〈781〉: between +219° and +229°, calculated on the dried basis, determined in a solution in alcohol containing 50 mg per 10mL.
