Camphor Spirit
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Camphor Spirit is an alcohol solution containing NLT 9.0 g and NMT 11.0 g of camphor (C H O) in each 100 mL.
Prepare Camphor Spirit as follows.
Camphor | 100 g |
Alcohol, a suffcient quantity to make | 1000 mL |
Dissolve the Camphor in 800 mL of the Alcohol, and add suffcient Alcohol to bring to final volume. Filter, if necessary.
2 ASSAY
Procedure
Sample: 2.0 mL
Analysis: Transfer the Sample to a suitable pressure bottle containing 50 mL of freshly prepared dinitrophenylhydrazine TS. Close the pressure bottle, immerse it in a water bath, and maintain at about 75° for 16 h. Cool to room temperature, and transfer the contents to a beaker with the aid of 100 mL of 3 N sulfuric acid. Allow to stand at room temperature for NLT 12 h, transfer the precipitate to a tared filter crucible, and wash with 100 mL of 3 N sulfuric acid followed by 75 mL of cold water in divided portions. Continue the suction until the excess water is removed, dry the crucible and precipitate at 80° for 2 h, cool, and weigh. The weight of the precipitate so obtained, multiplied by 0.4581, represents the weight of camphor (C H O) in the portion taken.
Acceptance criteria: 9.0–11.0 g of camphor in 100 mL
3 OTHER COMPONENTS
Alcohol Determination, Method II〈611〉
Test stock preparation: Dilute the Spirit with methanol to obtain a solution containing approximately 2% (v/v) of alcohol.
Acceptance criteria: 80.0%–87.0% of alcohol (C H OH)
4 ADDITIONAL REQUIREMENTS
Packaging and Storage: Package in tight containers.
