Calcium Lactate
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(CH3CHOHCOO)2Ca · 5H2O 308.29 CAS RN: 814-80-2.—White granules or powder. Is somewhat efforescent and at 120° becomes anhydrous. One g dissolves in 20 mL of water; practically insoluble in alcohol. Store it in tight containers.
Assay: Accurately weigh about 500 mg, previously dried at 120° for 4 hours, transfer to a suitable container, and dissolve in 150 mL of water containing 2 mL of diluted hydrochloric acid. Add 15 mL of sodium hydroxide TS and 300 mg of hydroxy naphthol blue indicator, and titrate with 0.05 M edetate disodium VS until the solution is deep blue. Each mL of 0.05 M edetate disodium is equivalent to 10.91 mg of C6H10CaO6. Not less than 98% is found.
LOSS ON DRYING (731): Dry it at 120° for 4 hours: it loses between 25.0% and 30.0% of its weight.
Acidity: Add phenolphthalein TS to 20 mL of a 1 in 20 solution, and titrate with 0.10 N sodium hydroxide: not more than 0.50 mL is required to produce a pink color.
Heavy Metals (Reagent test): Dissolve 1 g in 2.5 mL of diluted hydrochloric acid, dilute with water to 40 mL, and add 10 mL of hydrogen sulfide TS: any brown color produced is not darker than that of a control containing 0.02 mg of added Pb (0.002%).
Magnesium and Alkali Salts: Mix 1 g with 40 mL of water, carefully add 5 mL of hydrochloric acid, heat the solution, boil for 1 minute, and add rapidly 40 mL of oxalic acid TS. Add immediately to the warm mixture 2 drops of methyl red TS, then add ammonia TS dropwise, from a buret, until the mixture is just alkaline. Cool to room temperature, transfer to a 100-mL graduated cylinder, dilute with water to 100 mL, mix, and allow to stand for 4 hours or overnight. Filter, and transfer to a platinum dish 50 mL of the clear filtrate, to which has been added 0.5 mL of sulfuric acid. Evaporate the mixture on a steam bath to a small bulk. Carefully heat over a free flame to dryness, and continue heating to complete decomposition and volatilization of ammonium salts. Finally ignite the residue at 800 ± 25° for 15 minutes: the residue weighs not more than 5 mg (1%).
Volatile Fatty Acid: Stir about 500 mg with 1 mL of sulfuric acid, and warm: the mixture does not emit an odor of volatile fatty acid.
