Bis(trimethylsilyl)acetamide
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
(N,O-Bis(trimethylsil yl)acetamide; BSA), CH3CON[SI(CH3)3]2 203.43 CAS RN®: 10416-59-8.-Clear, colorless liquid. Readily hydrolyzes when exposed to moist air. Handle under nitrogen, and store in a cool place.
Assay: Not less than 90% of CH3CON[SI(CH3)3]2, a suitable gas chromatograph equipped with a thermal conductivity detector being used. The following conditions are suitable and provide a retention time of approximately 15 minutes.
Column: 3-mm x 1.83-m stainless steel containing 5% phase G1 on support S1A
Injection temperature: 160°
Column temperature: 90°, programmed to rise 4° per minute to 160°
Carrier gas: Helium
REFRACTIVE INDEX (831): between 1.4150 and 1.4170 at 20°.
