Bis(2-ethylhexyl)phosphoric Acid

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Bis(2-ethylhexyl)phosphoric Acid

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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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[Bis(2-ethylhexyl) Phosphate), [CH3(CH2)3CH(C2H5)CH2]2HPO4               322.42 CAS RN®: 298-07-7.-Light yellow, viscous liquid. Insoluble in water, freely soluble in chloroform and in ethyl acetate. Refractive index: about 1.443. Specific gravity: about 0.997.

Assay: Dissolve about 250 mg, accurately weighed, in 50 mL of dimethylformamide, add 3 drops of a 1 in 100 solution of thymol blue TS in dimethylformamide, and titrate with 0.1 N sodium methoxide VS to a blue endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N sodium methoxide is equivalent to 32.24 mg of (C8H17)2HPO4. Between 95% and 105% is found.

Solubility: One volume dissolves in 9 volumes of chloroform to yield a clear solution, and 1 volume dissolves in 9 volumes of ethyl acetate to yield a clear solution.

Color: A 1 in 100 solution in chloroform exhibits an absorptivity of not more than 0.03 at 420 nm.

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