Benzyl Benzoate Lotion
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Benzyl Benzoate Lotion contains NLT 26.0% and NMT 30.0% (w/w) of benzyl benzoate (C14H12O2).
| Benzyl Benzoate | 250 mL |
| Triethanolamine | 5 g |
| Oleic Acid | 20 g |
| Puried Water | 750 mL |
| To make about | 1000 mL |
Mix the Triethanolamine with the Oleic Acid, add the Benzyl Benzoate, and mix. Transfer the mixture to a suitable container of 2000-mL capacity, add 250 mL of Purified Water, and shake the mixture thoroughly. Add the remaining Purified Water, and again shake thoroughly.
2 ASSAY
PROCEDURE
Sample: 5 g of Lotion, accurately weighed, in a conical flask
Titrimetric system
(See Titrimetry (541),)
Mode: Residual titration
Titrant: 0.1 N sodium hydroxide VS
Back-titrant: 0.5 N hydrochloric acid VS
Endpoint detection: Visual
Analysis: To the Sample add 25 mL of alcohol and 2 drops of phenolphthalein TS. Cool the solution to 15°, and titrate quickly with Titrant to a slight pink color. Add 50.0 mL of 0.5 N alcoholic potassium hydroxide VS, connect the flask to a reflux condenser, and boil gently for 1 h. Cool. Promptly add phenolphthalein TS and titrate with Back-titrant. Perform a blank determination. Each mL of 0.5 N alcoholic potassium hydroxide is equivalent to 106.1 mg of benzyl benzoate (C14H12O2).
Acceptance criteria: 26.0%-30.0% (w/w)
3 SPECIFIC TESTS
PH (791): 8.5-9.2
4 ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Package in tight containers.
