Benzphetamine Hydrochloride,
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
C17H21N · HCI 275.82 CAS RN®: 5411-22-3.-White to off-white, crystalline powder. Freely soluble in water, in alcohol, and in chloroform; slightly soluble in ether.
Assay: Dissolve about 500 mg, accurately weighed, in a mixture of 50 mL of glacial acetic acid and 10 mL of mercuric acetate TS, add 1 drop of crystal violet TS, and titrate with 0.1 N perchloric acid VS to a blue-green endpoint. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N perchloric acid is equivalent to 27.58 mg of C17H21N · HCI. Between 98.0% and 101.0%, calculated on the dried basis, is found.
MELTING RANGE (741): between 152° and 158°,
SPECIFIC ROTATION (781); between +22° and +26°, determined in a solution containing 200 mg in 10 mL, the specimen having been previously dried in vacuum at 60° for 3 hours.
LOSS ON DRYING (731): Dry it in vacuum at 60° for 3 hours: it loses not more than 1% of its weight.
RESIDUE ON IGNITION (281): not more than 0.2%.
