Barium Sulfate for Suspension

This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition

Issued and maintained by the United States Pharmacopeial Convention (USP)

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1 DEFINITION

Barium Sulfate for Suspension is a dry mixture of Barium Sulfate and one or more suitable dispersing and/or suspending agents. It contains NLT 90.0% and NMT 110.0% of the labeled amount of barium sulfate (BaSO₄). It may contain one or more suitable colors, flavors, fluidizing agents, and preservatives.

2 IDENTIFICATION

A. Identification Tests—General, Sulfate 〈191〉

Sample: Ignite 1g to constant weight.

Analysis: Mix 0.5 g of the ignited Sample with 2 g each of anhydrous sodium carbonate and anhydrous potassium carbonate, heat the mixture in a crucible until fusion is complete, treat the resulting fused mass with hot water, and filter.

Acceptance criteria: The filtrate, acidified with hydrochloric acid, meets the requirements.

B. Identification Tests—General, Barium 〈191〉

Sample solution: Dissolve a portion of the well-washed residue from Identification test A in 6 N acetic acid.

Acceptance criteria: The solution meets the requirements.

3 ASSAY

Procedure

Sample: Barium Sulfate for Suspension, equivalent to 0.60 g of barium sulfate, weighed in a tared platinum crucible

Analysis: Ignite over a low flame until any organic matter is thoroughly carbonized. Cool, cautiously add 0.5 mL of nitric acid and 0.5 mL of sulfuric acid, and continue the ignition over a low flame until the residue becomes gray in color, then ignite over the full heat of a blast burner. Allow the contents of the crucible to cool to room temperature.

[Note—If the specimen contains a silicate, such as bentonite, proceed as follows. Add 10 mL of water and 1 mL of sulfuric acid to the residue in the crucible, mix, and add 10 mL of hydrofluoric acid. Heat gently over a low flame until fumes of sulfur trioxide appear. Add 5 mL more of hydrofluoric acid, heat again over a low flame to the appearance of dense fumes, and continue heating until the sulfuric acid has been completely volatilized. Allow the contents of the crucible to cool.]

[Note—If the specimen does not contain a silicate, omit the treatment of the specimen with hydrofluoric and sulfuric acids.]

Add to the treated or untreated specimen in the platinum crucible 10 g of anhydrous sodium carbonate, fuse over a blast burner until a clear melt is obtained, and heat for an additional 30 min. Cool, place the crucible in a 400-mL beaker, add 250 mL of water, stir with a glass rod, and heat to dislodge the melt. Remove the crucible from the beaker, and wash with water, collecting the washings in the beaker. Rinse the inside of the crucible with 2 mL of 6 N acetic acid and then with water, again collecting the washings in the beaker, and continue heating and stirring until the melt is disintegrated. Cool the beaker in an ice bath until the precipitate settles, and decant the clear liquid through filter paper (Whatman No. 40, or equivalent), taking care to transfer as little precipitate as possible to the paper.

Wash twice by decantation as follows. Wash down the inside of the beaker with 10 mL of cold sodium carbonate solution (1 in 50), swirl the contents of the beaker, allow the precipitate to settle, and decant the supernatant through the same filter paper as before, transferring as little precipitate as possible to the paper. Place the beaker containing the bulk of the barium carbonate precipitate under the funnel, wash the filter paper with five 1-mL portions of 3 N hydrochloric acid, and wash the paper with water. [Note—The solution may be slightly hazy.]

Add 100 mL of water, 5.0 mL of hydrochloric acid, 10.0 mL of ammonium acetate solution (2 in 5), 25 mL of potassium dichromate solution (1 in 10), and 10.0 g of Urea. Cover the beaker with a watch glass, and digest at 80°–85° for NLT 16 h. Filter while hot through a tared, fine-porosity, sintered-glass crucible, transferring all of the precipitate with the aid of a rubber-tipped stirring rod. Wash the precipitate with potassium dichromate solution (1 in 200), and finally with 20 mL of water. Dry at 105° for 2 h, cool, and weigh. The weight of the barium chromate so obtained, multiplied by 0.9213, represents the weight of barium sulfate (BaSO₄).

Acceptance criteria: 90.0%–110.0%

4 SPECIFIC TESTS

Loss on Drying 〈731〉

Analysis: Dry at 105° for 4 h.

Acceptance criteria: NMT 1.0%

pH 〈791〉: 3.5–10.0, in a 60% (w/w) aqueous suspension, or constituted for its intended use as directed in the labeling

5 ADDITIONAL REQUIREMENTS

Packaging and Storage: Preserve in well-closed containers.