Atenolol Compounded Oral Solution
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
1 DEFINITION
Atenolol Compounded Oral Solution contains NLT 90.0% and NMT 110.0% of the labeled amount of atenolol (C14H22N2O3).
Prepare Atenolol Compounded Oral Solution at a 2-mg/mL concentration, for example, as follows (see Pharmaceutical Compounding—Nonsterile Preparations 〈795〉)
| Atenolol | 200 mg |
| Glycerin | 5 mL |
| Vehicle for Oral Suspension | 45 mL |
| Vehicle for Oral Solution, Sugar Free, a sucient quantity to make | 100 mL |
Calculate the quantity of each ingredient required for the total volume and atenolol strength to be prepared. Mix the Atenolol, previously pulverized, and Glycerin to form a smooth paste. Incorporate the Vehicle for Oral Suspension or an equal volume of Vehicle for Oral Solution, Sugar Free [NOTE-The Vehicle for Oral Suspension may be omitted.) Incorporate sufficient Vehicle for Oral Solution, Sugar Free in increments to bring to volume, and mix well. [NOTE-Do not use a sucrose-containing vehicle for oral solution.] Package, and label.
2 ADDITIONAL REQUIREMENTS
PACKAGING AND STORAGE: Package in amber, tight containers, and store at controlled room temperature.
BEYOND-USE DATE: NMT 60 days after the day on which it was compounded when stored at controlled room temperature
LABELING: Label it to state that it is to be shaken well before use, and to state the Beyond-Use Date.
