Ammoniated Mercury
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This article is compiled based on the United States Pharmacopeia (USP) – 2025 Edition
Issued and maintained by the United States Pharmacopeial Convention (USP)
Hg(NH2)Cl 252.07
Mercury amide chloride CAS RN®: 10124-48-8; UNII: JD546Z56F0.
1 DEFINITION
Ammoniated Mercury contains NLT 98.0% and NMT 100.5% of ammoniated mercury [Hg(NH2)Cl].
2 IDENTIFICATION
A.
Sample: 0.1 g
Analysis: Place the Sample in a cold solution of 1 g of sodium thiosulfate in 2 mL of water.
Acceptance criteria: The Sample is soluble, with the evolution of ammonia. When this solution is heated gently, a rust-colored mixture is formed, from which a red precipitate is obtained on centrifugation. If the solution is strongly heated, a black mixture forms.
B.
Sample: A suitable quantity
Analysis: Heat the Sample with 1 N sodium hydroxide.
Acceptance criteria: The solution becomes yellow, and ammonia is evolved.
C.
Sample solution: A suitable quantity in warm acetic acid
Analysis: Sample solution with potassium iodide TS
Acceptance criteria: The solution yields a red precipitate that is soluble in an excess of the reagent. The solution yields a white precipitate with silver nitrate TS.
3 ASSAY
Procedure
Sample solution: Mix 0.25 g of Ammoniated Mercury with 10 mL of water. Add 3 g of potassium iodide, mix occasionally until dissolved, add about 40 mL of water, and add methyl red TS.
Analysis: Titrate with 0.1 N hydrochloric acid VS. Perform a blank determination, and make any necessary correction. Each mL of 0.1 N hydrochloric acid is equivalent to 12.60 mg of ammoniated mercury [Hg(NH2)Cl].
Acceptance criteria: 98.0%–100.5%
4 IMPURITIES
Residue on Ignition 〈281〉: NMT 0.2%
Mercurous Compounds
Sample: 2.5 g
Analysis: Dissolve the Sample in 25 mL of warm hydrochloric acid. Pass through a tared filtering crucible, wash with water, and dry at 60° to constant weight.
Acceptance criteria: NMT 0.2%; the weight of the residue does not exceed 5 mg.
5 ADDITIONAL REQUIREMENTS
Packaging and Storage: Preserve in well-closed, light-resistant containers.
